HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 66636497, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | Ethyl 4-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carboxylate | HCID 66636407 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 66636497 | HCID 66636497 | — |
Reaction Steps
To a solution of the product obtained in Step H (0.2 g) in THF (10 ml) at 0° C. there is added, in portions, lithium aluminium hydride. After stirring for 3 hours at ambient temperature, the reaction mixture is hydrolysed at 0° C. with aq. NaOH solution and water. After filtration, the filtrate is evaporated to dryness and the residue obtained is purified on silica gel (SiO2: gradient CH2Cl2/MeOH with the addition of 1.4N NH3 in the MeOH) to yield the title product, which is used directly in the next Step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541412B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-1f25ad390679412e8aeeafc74b74ab3c |
| Source note | uspto-grants-2013_09 |