HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 7,8-Methylenedioxy-1-(4-methylphenyl)-3,5-dihydro-2,3-benzodiazepin-4(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 2-(4-Methylbenzoyl)-4,5-methylenedioxyphenylacetate | HCID 10710218 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 7,8-Methylenedioxy-1-(4-methylphenyl)-3,5-dihydro-2,3-benzodiazepin-4(4H)-one | HCID 10685192 | — |
Reaction Steps
The title compound was prepared from methyl 4,5-methylenedioxy-2-(4-methylbenzoyl)phenylacetate (90 mg, 0.29 mmol), hydrazine hydrate (50 μL, 0.88 mmol) and acetic acid (40 μL) in ethanol (10 mL), mp: 222°-224° C. 1H NMR (CDCl3) 8.36 (s, 1H), 7.48 (d, 2H, J=8.0), 7.23 (d, 2H, J=8.0), 6.82 (s, 1H), 6.64 (s, 1H), 6.02 (s, 2H), 3.45 (s, 2H), 2.41 (s, 3H). Anal. Calcd. for C17H14N2O3 : C, 69.38; H, 4.79; N, 9.52. Found: C, 69.14; H, 4.80; N, 9.30.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05891871 |
| Source dataset | uspto-grants-1999_04 |
| ORD ID | ord-f8e5f502c3da49f8b7ef411e25b66e70 |
| Source note | uspto-grants-1999_04 |