HCID 9839097, compound → HCID 54343162, compound

Participants

Reaction Steps

To a solution of 1-(4-aminophenyl)-7,8-methylenedioxy-3,5-dihydro-2,3-benzodiazepin-4(4H)-one (119 mg, 0.403 mmol) in acetic acid (2 mL) was added NaOCN (38 mg, 0.58 mmol) at room temperature. The mixture was stirred at room temperature for 4 h, diluted with EtOAc (80 mL), washed with 2 N NaOH, water and brine, dried over Na2SO4 and concentrated in vacuo. The residue was purified by chromatography to afford the title compound as a yellow solid (40 mg, 0.12 mmol, 30%), mp: 238°-241° C. 1H NMR (DMSO-d6) 10.79 (s, 1H), 8.77 (s, 1H), 7.47 (d, J=8.7, 2H), 7.40 (d, J=8.7, 2H), 7.07 (s, 1H), 6.61 (s, 1H), 6.10 (s, 2H), 5.95 (s, 2H), 3.33 (s, 2H).

Provenance & Evidence