Adenine → HCID 15858375, compound

Participants

Reaction Steps

A mixture of adenine (0.829 g, 6.10 mmol), anhydrous potassium carbonate (45 mg) and rac-1,2-epoxy-3-octadecylthiopropane (2.0 g, 5.83 mmol) in anhydrous dimethyl formamide (10 mL) is stirred at 70°-75° C. for 20 hours under a nitrogen atmosphere. The reaction mixture is filtered directly without cooling and the filtrate is concentrated under reduced pressure to afford a white residue. The residue is stirred with 95:5 (v/v) chloroform-methanol. The insoluble solid is filtered, purified by chromatography, and dried in vacuo to 9-[2'-hydroxy-3'-octadecylthiopropyl]-adenine.

Provenance & Evidence