Potassium Iodide → N,N-dimethyl N'-[2-(3-pyridyl)ethyl]ethanediamine

Participants

Reaction Steps

11 g of 3-(2-chloroethyl)pyridine hydrochloride, 16.3 g of N,N-dimethylmethane diamine, 18.5 g of sodium bicarbonate and 13 g of potassium iodide are heated in 150 ml of ethanol for about 30 hours at about 60° C. The solvent is evaporated and the residue is taken up in 100 ml of water before an aqueous solution of 10N NaOH is added to give pH 8; the aqueous phase is then extracted 3 times with 80 ml of ethyl acetate. The pooled organic phases are dried over magnesium sulfate, filtered and concentrated under reduced pressure. The residual oil is distilled to give 6.7 g of the expected product. B.p.=100°-107° C./10 Pa.

Provenance & Evidence