Pyridine → 5-Chloro 3-(2,4-dimethylphenyl) 1,2,4-oxadiazole

HRID 442717Notes

Reaction equation

HRID 442717 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4](=[N:6][OH:7])[NH2:5].N1C=CC=CC=1.[Cl:19][C:20](OCC)=O>C1(C)C=CC=CC=1>[Cl:19][C:20]1[O:7][N:6]=[C:4]([C:3]2[CH:8]=[CH:9][C:10]([CH3:12])=[CH:11][C:2]=2[CH3:1])[N:5]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 10928Ethyl chloroformateHCID 4328521N'-hydroxy-2,4-dimethylbenzenecarboximidamide

Product 1

HCID 541873755-Chloro 3-(2,4-dimethylphenyl) 1,2,4-oxadiazole

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Under an inert atmosphere, 10.5 g of 2,4-dimethyl benzamidoxime are dissolved in 40 ml of anhydrous toluene; 6.5 ml of pyridine and 7.6 g of ethyl chloroformate are added.

Sources & evidence

ORD record
ord-9b73009b92c14186be6c4f667bc58495
Source dataset
uspto-grants-1999_04
Patent number
US05891893

Reaction notes

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