関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Methyl iodide | HCID 6328 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 6-Methylindole-3-carboxaldehyde | HCID 4777902 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1,6-Dimethyl-1H-indole-3-carbaldehyde | HCID 22593746 | 97% |
反応手順
A solution of the known 6-methyl-1H-indole-3-carboxaldehyde (5 g, 31 mm) in DMF (100 mL) was cooled to 0° C. and treated with NaH (38 mm), and stirred at 0° C. for 3 hours. After treatment with CH3I (2.35 mL, 38 mm), the mixture was allowed to warm to room temperature overnight. The mixture was poured into H2O(500 mL) and extracted with ethylacetate (EtOAc) (200 mL×3). The combined organic layers were dried over MgSO4, filtered and evaporated. Purification by flash column chromatography afforded 1,6-dimethyl-1H-indole-3-carboxaldehyde (5.2 g, 97%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05891901 |
|---|
| 出典データセット | uspto-grants-1999_04 |
|---|
| ORD ID | ord-56cb28cf919340c083e1a725acc2a2fc |
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| 出典メモ | uspto-grants-1999_04 |
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