反应详情

温度

215 °C

A mixture of 6-methylsulfanyl-1H-indole-2-carboxylic acid (9.6 g, 46 mmol), Cu powder (2.1 g, 33 mmol) and quinoline (100 ml) was heated at 215° C. for 3 hours. The mixture was cooled to room temperature, filtered through celite, and the filtrate diluted with H2O (500 mL). The cooled mixture was acidified with concentrated HCl (pH=1), and extracted with EtOAc. The organic fraction was washed with saturated NaCl solution, dried over MgSO4, filtered and evaporated to give of 6-Methylsulfanyl-1H-indole (6.8 g, 90%) after purification by flash column chromatography.

1. temperatureThe mixture was cooled to room temperature
2. filtrationfiltered through celite
3. additionthe filtrate diluted with H2O (500 mL)
4. extractionextracted with EtOAc
5. washThe organic fraction was washed with saturated NaCl solution
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customevaporated