Hydrochloric Acid → HCID 53730750, compound

Participants

Reaction Steps

3-(6-hydroxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione was prepared by treating Benzenesulfonic acid 1-methyl-3-[4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-1H-indol-6-yl ester (141 mg 0.28 mm) with 4N NaOH (0.5 mL, 2 mmol) and CH3OH (4 mL) and heating to reflux temperature for 6 hours. After cooling to room temperature, the reaction mixture was diluted with H2O, acidified with 2N HCl, and extracted with EtOAc. The organic phase was washed with saturated NaCl solution, dried over MgSO4, filtered and evaporated to afford, after purification by flash column chromatography 3-(6-hydroxy-1-methyl-1H-indol-3-yl)-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione (15 mg); mp=279°-282° C.

Provenance & Evidence