HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(Aminomethyl)indolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Oxo-2,3-dihydro-1H-indole-5-carbonitrile | HCID 2773346 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(Aminomethyl)indolin-2-one | HCID 17982555 | — |
Reaction Steps
A solution of the compound obtained in Step B (35 mmoles) in MeOH (500 ml) is added to 6 ml of concentrated HCl. The reaction mixture is stirred for 3 days under 10 bars of hydrogen. After filtration over Celite, the filtrate is evaporated to dryness to yield the title product in the form of a white powder, which is used directly in the next reaction.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08541412B2 |
| Source dataset | uspto-grants-2013_09 |
| ORD ID | ord-f36035f27dc442fb898472ec95dcdb87 |
| Source note | uspto-grants-2013_09 |