反应详情

To a stirred solution of ethyl 3-methoxy-4-methoxycarbonylbenzoylacetate (4.1 g, 14.6 mmol) in a mixture of ethanol (30 ml) and acetic acid (30 ml) was added portionwise 9-hydroxyxanthene (3.2 g, 16.1 mmol). After stirring for 2 weeks at room temperature, the solution was concentrated in vacuo, diluted with water and extracted with dichloromethane (2×). The combined extracts were washed with a saturated solution of sodium bicarbonate, water and dried over magnesium sulphate. Filtration and evaporation gave ethyl 2-(9H-xanthen-9-yl)-2-(3-methoxy-4-methoxycarbonyl-benzoyl)acetate as an oil.

1. concentrationthe solution was concentrated in vacuo
2. additiondiluted with water
3. extractionextracted with dichloromethane (2×)
4. washThe combined extracts were washed with a saturated solution of sodium bicarbonate, water
5. dry with materialdried over magnesium sulphate
6. filtrationFiltration and evaporation