Boron tribromide → HCID 54141791, compound

Participants

Reaction Steps

To a suspension of 2-amino-2-(4-carboxy-3-methoxyphenyl)-3-(9H-xanthen-9-yl)propanoic acid (140 mg, 0.33 mmol) in dry dichloromethane (10 ml) was added a solution of boron tribromide in dichloromethane (1.0M, 0.7 ml). The resulting suspension was stirred at room temperature for 3 days, diluted with water and stirred a further 2 h. The dichloromethane layer was separated and the aqueous phase purified by ion exchange as described in Example 1 (vi). The water-tetrahydrofuran fractions were found to contain the desired product and were combined, evaporated and freeze-dried from water to give the title compound as a white powder, m.p. 191°-194° C.

Provenance & Evidence