HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monoethyl malonate → Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monoethyl malonate | HCID 70615 | — |
| Reactant | Lithium, mol. (Li2) | HCID 139759 | — |
| Reactant | 4-Bromo-2-methylbenzoyl chloride | HCID 12846483 | — |
| Product | Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate | HCID 53404613 | — |
Reaction Steps
2-Methyl-4-bromobenzoyl chloride (29.1 g, 0.13 mol) was treated with the dilithium salt of ethyl hydrogen malonate (28.0 g, 0.21 mol) and the product was isolated by the procedure described in Example 1 (ii). The crude product was purified on flash silica, eluting with dichloromethane-hexane (1:1 then 3:2) to give ethyl 2-methyl-4-bromobenzoylacetate as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05891899 |
| Source dataset | uspto-grants-1999_04 |
| ORD ID | ord-ddc09ecaf6e64ae8b211449d5c77514a |
| Source note | uspto-grants-1999_04 |