Potassium Cyanide → HCID 53772933, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 1-(4-cyano-2-methylphenyl)-2-(9H-xanthen-9-ylmethyl)ethanone (6.3 g, 18.6 mmol), potassium cyanide (2.2 g, 33.4 mmol) and ammonium carbonate (6.42 g, 66.9 mmol) in ethanol (9 ml) and water (9 ml) was heated at 85° C. for 2 days and then 100° C. for 3 days and finally 120° C. for 1 day in a teflon lined stainless steel sealed tube. The reaction was worked up as in Example 1 (v) to give a red oil. Purification on flash silica eluting with ethyl acetate-hexane (2:3 then 1:1 then 3:2) gave 5-(4-cyano-2-methylphenyl)-5-(9H-xanthen-9-ylmethyl)hydantoin as a pale yellow solid, m.p. 148°-152° C.

Provenance & Evidence