反应详情

5-(4-Cyanophenyl)-5-(9H-thioxanthen-9-ylmethyl)hydantoin (2.3 g, 5.5 mmol) was hydrolysed in aqueous sodium hydroxide (16.5 ml) following the procedure described in Example 1 (vi) for 72 h at 150° C. The cooled reaction mixture was then acidified with acetic acid, the resulting solid precipitate was filtered and washed with diethylether to give an off white solid. The solid was redissolved in aqueous sodium hydroxide (2M), filtered through a celite pad and acidified with acetic acid, filtered, washed with water, diethylether and finally methanol and then dried in vacuo to give the title compound as a white solid, m.p. 251° C.

1. customThe cooled reaction mixture
2. filtrationthe resulting solid precipitate was filtered
3. washwashed with diethylether
4. customto give an off white solid
5. filtrationfiltered through a celite pad
6. filtrationfiltered
7. washwashed with water, diethylether and finally methanol
8. customdried in vacuo