Trimethylsilyl iodide → HCID 54399964, compound

Participants

Reaction Steps

To a suspension of 2-amino-3-(9H-xanthen-9-yl)-2-(4-diethylphosphonophenyl)propanoic acid (114 mg, 0.25 mmol) in dry dichloromethane (10 ml) stirred under an atmosphere of nitrogen was added trimethylsilyl iodide (0.26 g, 1.29 mmol). The resulting solution was stirred at room temperature for 24 h and then further trimethylsilyl iodide (0.26 g, 1.29 ml) added. Stirring was continued for 5 h, the reaction mixture evaporated to dryness and redissolved in water. Ion exchange chromatography using the conditions described in Example 1 (vi) gave the title compound as a pale yellow powder.

Provenance & Evidence