HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) → 1-{3-{Bis[4-(methoxymethoxy)phenyl]methyl}-1-(2-morpholinoethyl)indol-2-ylcarbonyl}-4-(2-chlorophenyl)-piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine, 4-(2-chloroethyl)-, hydrochloride (1:1) | HCID 77210 | — |
| Reactant | 1-{3-{Bis[4-(methoxymethoxy)phenyl]methyl}indol-2-ylcarbonyl}-4-(2-chlorophenyl)piperazine | HCID 15858901 | — |
| Product | 1-{3-{Bis[4-(methoxymethoxy)phenyl]methyl}-1-(2-morpholinoethyl)indol-2-ylcarbonyl}-4-(2-chlorophenyl)-piperazine | HCID 15858907 | 89% |
Reaction Steps
Substantially the same procedure as in Example 2 was repeated using Compound 1 (2.0 g, 3.19 mmol) obtained in Example 1 and 2-morpholinoethylchloride hydrochloride (600 mg, 3.19 mmol) to give 2.1 g (yield: 89%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05891902 |
| Source dataset | uspto-grants-1999_04 |
| ORD ID | ord-232ae2640bd3490cb47e7c02db9a9e98 |
| Source note | uspto-grants-1999_04 |