p,p'-Dimethoxybenzhydryl alcohol → HCID 70147134, compound

HRID 442853Notes

Reaction equation

HRID 442853 reaction equation
[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7](O)[C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1.[Cl:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][N:29]([C:32]([C:34]2[NH:35][C:36]3[C:41]([CH:42]=2)=[CH:40][CH:39]=[CH:38][CH:37]=3)=[O:33])[CH2:28][CH2:27]1>>[CH3:1][O:2][C:3]1[CH:18]=[CH:17][C:6]([CH:7]([C:8]2[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=2)[C:42]2[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[NH:35][C:34]=2[C:32]([N:29]2[CH2:28][CH2:27][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[Cl:19])[CH2:31][CH2:30]2)=[O:33])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 69768p,p'-Dimethoxybenzhydryl alcoholHCID 17877334HCID 17877334, compound

Product 1

HCID 70147134HCID 70147134, compoundYield 81%

Procedure

Substantially the same procedure as in Example 1 was repeated using 4,4'-dimethoxybenzhydrol (2.37 g, 9.71 mmol) and 1-(2-chlorophenyl)-4-(indol-2-ylcarbonyl)piperazine (3.0 g, 8.83 mmol) to give 4.0 g (yield: 81%) of the title compound.

Sources & evidence

ORD record
ord-401994d8d4114afb9a0596f68bea4091
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

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