1-(2-Chloroethyl)pyrrolidine hydrochloride → HCID 15858913, compound

HRID 442861Notes

Reaction equation

HRID 442861 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[NH:17][C:18]3[C:23]([C:24]=2[CH:25]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])[CH2:10][CH2:9]1.Cl.[N:39]1([CH2:44][CH2:45]Cl)[CH2:43][CH2:42][CH2:41][CH2:40]1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[N:8]1[CH2:13][CH2:12][N:11]([C:14]([C:16]2[N:17]([CH2:45][CH2:44][N:39]3[CH2:43][CH2:42][CH2:41][CH2:40]3)[C:18]3[C:23]([C:24]=2[CH:25]([C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=2)[C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)=[CH:22][CH:21]=[CH:20][CH:19]=3)=[O:15])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 816681-(2-Chloroethyl)pyrrolidine hydrochlorideHCID 15858911HCID 15858911, compound

Product 1

HCID 15858913HCID 15858913, compoundYield 54%

Procedure

Substantially the same procedure as in Example 89 was repeated using Compound 88 (0.95 g, 1.88 mmol) obtained in Example 88 and 2-pyrrolidinylethylchloride hydrochloride (335 mg, 1.97 mmol) to give 0.61 g (yield: 54%) of the title compound.

Sources & evidence

ORD record
ord-ccb36ba8a7a54d50b1bcf81ab695818c
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

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