Sodium Hydroxide → HCID 22440043, compound

Participants

Reaction Steps

Compound 92 (7.0 g, 16.5 mmol) obtained in Example 92 was dissolved in ethanol (50 ml), and a 2N aqueous sodium hydroxide solution (25 ml) was added thereto, followed by heating under reflux. After 4 hours, a 2N aqueous sodium hydroxide solution (10 ml) was added thereto, followed by heating under reflux for one hour. The reaction solution was concentrated under reduced pressure, water was added, and the pH of the solution was adjusted to 5. A little amount of chloroform was added to the mixture followed by stirring. The precipitated crystals were collected by filtration, washed with water, and dried under reduced pressure to give 5.7 g (yield: 87%) of the title compound.

Provenance & Evidence