N,N-Dimethylaminoethyl chloride hydrochloride → HCID 54138561, compound

HRID 442872Notes

Reaction equation

HRID 442872 reaction equation
[C:1]1([CH:7]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[NH:10][C:9]=2[S:17]([N:20]2[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]2)(=[O:19])=[O:18])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:33][N:34]([CH3:38])[CH2:35][CH2:36]Cl>>[CH3:33][N:34]([CH3:38])[CH2:35][CH2:36][N:10]1[C:11]2[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8]([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[C:9]1[S:17]([N:20]1[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25]1)(=[O:18])=[O:19]

Participants

3

Reactant 2

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochlorideHCID 54381562HCID 54381562, compound

Product 1

HCID 54138561HCID 54138561, compoundYield 75.3%

Procedure

Substantially the same procedure as in Example 243 was repeated using Compound 263 (1.0 g, 2.25 mmol) obtained in Example 264 and 2-dimethylaminoethylchloride hydrochloride (360 mg, 2.47 mmol) to give 0.85 g (yield: 75%) of the title compound.

Sources & evidence

ORD record
ord-e9cf3603991d4f46b43a70ba2ba16b20
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

Loading…