HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-4-chlorobutane → 1-{3-{Bis[4-(methoxymethoxy)phenyl]methyl}-1-(4-chlorobutyl)indol-2-ylcarbonyl}-4-(2-chlorophenyl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-4-chlorobutane | HCID 81364 | — |
| Reactant | 1-{3-{Bis[4-(methoxymethoxy)phenyl]methyl}indol-2-ylcarbonyl}-4-(2-chlorophenyl)piperazine | HCID 15858901 | — |
| Product | 1-{3-{Bis[4-(methoxymethoxy)phenyl]methyl}-1-(4-chlorobutyl)indol-2-ylcarbonyl}-4-(2-chlorophenyl)piperazine | HCID 70144103 | 93% |
Reaction Steps
Substantially the same procedure as in Reference Example 2 was repeated using Compound 1 (5.0 g, 7.99 mmol) and 1-bromo-4-chlorobutane (1.0 ml, 8.78 mmol) to give 5.3 g (yield: 93%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05891902 |
| Source dataset | uspto-grants-1999_04 |
| ORD ID | ord-6b31bfdda20c4fd28ef9e7cc5858c77f |
| Source note | uspto-grants-1999_04 |