Ethyl indole-2-carboxylate → HCID 67594464, compound

HRID 442885Notes

Reaction equation

HRID 442885 reaction equation
[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][O:5][C:6]1[CH:19]=[CH:18][C:9]([CH:10](O)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=1.[NH:21]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[C:22]1[C:30]([O:32][CH2:33][CH3:34])=[O:31]>>[CH3:1][N:2]([CH3:20])[CH2:3][CH2:4][O:5][C:6]1[CH:19]=[CH:18][C:9]([CH:10]([C:23]2[C:24]3[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=3)[NH:21][C:22]=2[C:30]([O:32][CH2:33][CH3:34])=[O:31])[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 53921106HCID 53921106, compound

Product 1

HCID 67594464HCID 67594464, compoundYield 86.2%

Procedure

Substantially the same procedure as in Reference Example 5 was repeated using 4-(2-dimethylaminoethoxy)benzhydrol (14.78 g, 54.5 mmol) and ethyl indole-2-carboxylate (11.3 g, 59.9 mmol) to give 20.8 g (yield: 86%) of the title compound.

Sources & evidence

ORD record
ord-70ee7edb2a55481a9d8f606a54b7346c
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

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