Ethyl indole-2-carboxylate → HCID 67594328, compound

HRID 442886Notes

Reaction equation

HRID 442886 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:22]=[CH:21][C:12]([CH:13](O)[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:23]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[C:24]1[C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:22]=[CH:21][C:12]([CH:13]([C:25]3[C:26]4[C:31](=[CH:30][CH:29]=[CH:28][CH:27]=4)[NH:23][C:24]=3[C:32]([O:34][CH2:35][CH3:36])=[O:33])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 10518129HCID 10518129, compound

Product 1

HCID 67594328HCID 67594328, compound

Procedure

Substantially the same procedure as in Reference Example 5 was repeated using 4-(2-pyrrolidinylethoxy)benzhydrol (19.4 g, 65.1 mmol) and ethyl indole-2-carboxylate (13.55 g, 71.6 mmol) to give 31.2 g (quantitative) of the title compound.

Sources & evidence

ORD record
ord-2dfdce66be7140dfa33ee86bea475906
Source dataset
uspto-grants-1999_04
Patent number
US05891902

Reaction notes

Loading…