Benzhydrol → HCID 67594354, compound

HRID 442891Notes

Reaction equation

[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][CH2:9][NH:10][S:11]([C:14]1[N:15]([S:23]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)(=[O:25])=[O:24])[C:16]2[C:21]([CH:22]=1)=[CH:20][CH:19]=[CH:18][CH:17]=2)(=[O:13])=[O:12].[CH:32](O)([C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)[C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[C:33]1([CH:32]([C:39]2[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=2)[N:10]([CH2:9][CH2:8][CH2:7][N:3]2[CH2:4][CH2:5][CH2:6][C:2]2=[O:1])[S:11]([C:14]2[N:15]([S:23]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)(=[O:25])=[O:24])[C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][CH:17]=3)(=[O:12])=[O:13])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

Reactant 2

HCID 7037Benzhydrol

HCID 67595047HCID 67595047, compound

Product 1

HCID 67594354HCID 67594354, compoundYield 36%

Procedure

Substantially the same procedure as in Reference Example 36 was repeated using N-[3-(2-oxopyrrolidinyl)propyl]-1-benzenesulfonylindole-2-sulfonamide (10.0 g, 21.67 mmol) and benzhydrol (6.00 g, 32.50 mmol) to give 4.85 g (yield: 36%) of the title compound.

Sources & evidence

ORD record: ord-e712e074d25043b5bd85d25672a34c02
Source dataset: uspto-grants-1999_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05891902

Reaction notes

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