Dimethyl Sulfoxide → 3-[3-(3-Chlorophenylsulfonyloxy)-5-methylphenoxy]propionaldehyde

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Reaction Steps

Sulfur trioxide pyridine complex (480 mg, 4.0 mmol) was added to a solution of 3-[3-(2,3-dichlorophenylsulfonyloxy)-5-methylphenoxy]propanol (460 mg, 1.3 mmol), as prepared in the preceding step, N,N-diisopropylethylamine (0.5 mL, 3.9 mmol) and anhydrous dimethyl sulfoxide (0.3 mL, 4.2 mmol) in anhydrous dichloromethane (10 mL). The reaction mixture was stirred at ambient temperature for 1 hour and then quenched with 10% aqueous citric acid (50 mL). The mixture was extracted into dichloromethane (3×50 mL), and the dichloromethane solution was washed with 10% aqueous citric acid (40 mL) and dried over Na2SO4. After removing the solvent in vacuo, the residue was purified by flash column chromatography (dichloromethane) to give the title compound as a colorless oil (420 mg, 91%). 1H-NMR (300 MHz, CDCl3) δ 9.84 (s, 1H), 7.86 (s, 1H), 7.74 (d, J=7.9 Hz, 1H), 7.64 (d, J=8.0 Hz, 1H), 7.49 (t, J=8.0 Hz, 1H), 6.63 (s, 1H), 6.44 (s, 1H), 6.37 (s, 1H), 4.20 (t, J=6.1 Hz, 2H), 2.87 (t, J=6.1 Hz, 2H), 2.26 (s, 3H).

Provenance & Evidence