Dimethyl Sulfoxide → HCID 54438747, compound

Participants

Reaction Steps

A solution of 3-[5-methyl-3-[2-(methylsulfonyl)phenylsulfonyloxy]-phenoxy]propanol (1.16 g, 2.9 mmol), as prepared in the preceding step, anhydrous dimethyl sulfoxide (0.62 mL, 8.7 mmol), and N,N-diisopropylethylamine (1.0 mL, 6.1 mmol) in anhydrous dichloromethane (30 mL) was treated with sulfur trioxide pyridine complex (0.97 g 6.1 mmol) at 0° C. The reaction mixture was stirred for 0.75 h before quenching with 10% aqueous citric acid (40 mL). The dichloromethane layer was separated and the aqueous layer was extracted with dichloromethane (4×40 mL). The dichloromethane layers were combined and washed with brine, dried, and evaporated to dryness. The material was used without purification in the next step.

Provenance & Evidence