HCID 15331970, compound → HCID 11851005, compound

HRID 443007Notes

Reaction equation

HRID 443007 reaction equation
[Si:1]([O:8][C@@H:9]1[C@@H:13]([CH2:14][CH2:15][OH:16])[O:12][C@@H:11]([N:17]2[CH:25]=[C:23]([CH3:24])[C:21](=[O:22])[NH:20][C:18]2=[O:19])[CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[Si](O[C@@H]1[C@@](C=O)(CO)O[C@@H](N2C=C(C)C(=O)NC2=O)C1)(C(C)(C)C)(C)C>>[Si:1]([O:8][C@@H:9]1[C@@H:13]([CH2:14][CH:15]=[O:16])[O:12][C@@H:11]([N:17]2[CH:25]=[C:23]([CH3:24])[C:21](=[O:22])[NH:20][C:18]2=[O:19])[CH2:10]1)([C:4]([CH3:7])([CH3:5])[CH3:6])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 15331970HCID 15331970, compoundHCID 18650251HCID 18650251, compound

Product 1

HCID 11851005HCID 11851005, compound

Procedure

3'-O-t-Butyldimethylsilyl-5'-deoxy-5'-hydroxymethyl thymidine was oxidized to the title aldehyde using the same procedure as described for 3'-O-t-butyl-dimethylsilyl thymidine 4'-aldehyde in Example 11.

Sources & evidence

ORD record
ord-787388dc4bcf4b9fbd439bee0ca21e22
Source dataset
uspto-grants-1999_04
Patent number
US05892024

Reaction notes

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