Sodium hydride → HCID 54232873, compound

Participants

Reaction Steps

To a solution of bis(4-methoxyphenyl)acetonitrile (1.0 g, 4 mmol) in N,N-dimethylformamide (5 ml) was added 60% oil sodium hydride (0.24 g, 6 mmol) while stirring under ice-cooling. The mixture was stirred for 30 minutes under the same conditions, to which was added, while stirring under ice-cooling, ethyl 6-bromohexanoate (0.89 g, 4 mmol). The mixture was stirred for 2 hours at room temperature, to which was added a saturated aqueous solution of ammonium chloride. The mixture was subjected to extraction with ethyl acetate. The organic layer was washed with water and a saturated aqueous saline solution, which was dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was subjected to a silica gel column chromatography, eluting with hexane--ethyl acetate (4:1) to give 1.1 g of the title compound.

Provenance & Evidence