Boron tribromide → HCID 54549095, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 7-cyano-7,7-bis(4-methoxyphenyl)heptanoate (2.0 g, 5 mmol.) in dichloromethane (20 ml) was added dropwise a solution of boron tribromide (5.07 g, 20 mmol.) in dichloromethane (15 ml) while stirring at -70° C. The reaction mixture was warmed up to 5° C. taking 2 hours, to which was added ice-water, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous saline solution and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure, and the residue was subjected to a silica gel column chromatography, eluting with hexane--ethyl acetate (2:1), to afford the title compound (1.7 g).

Provenance & Evidence