4'-(Bromomethyl)-2-cyanobiphenyl → 2-Cyano-4'-methylbiphenyl

Participants

Reaction Steps

After the dropwise addition of the solution prepared by dissolving the mixture of 4'-dibromomethyl-2-cyanobiphenyl and 4'-bromomethyl-2-cyanobiphenyl in toluene was terminated, the mixture was allowed to react up to a point where the above suspension no longer absorbs hydrogen gas. After the reaction was terminated, Raney catalyst and sodium carbonate were filtered off, and the reaction mixture was then concentrated to distill off methanol and toluene. The resulting crude 4'-methyl-2-cyanobiphenyl was purified by distillation, to give 7.4 g of 4'-methyl-2-cyanobiphenyl having an LC purity of 98.2%.

Provenance & Evidence