4'-(Bromomethyl)-2-cyanobiphenyl → 2-Cyano-4'-methylbiphenyl

Participants

Reaction Steps

After the dropwise addition of the solution prepared by dissolving the mixture of 4'-dibromomethyl-2-cyanobiphenyl and 4'-bromomethyl-2-cyanobiphenyl in toluene was terminated, the mixture was allowed to react up to a point where the above suspension no longer absorbs hydrogen gas. After the reaction was terminated, Pt--C and sodium hydroxide were filtered off, and the reaction mixture was then concentrated to distill off methanol and toluene. The resulting crude 4'-methyl-2-cyanobiphenyl was purified by distillation, to give 21.7 g of 4'-methyl-2-cyanobiphenyl having an LC purity of 98.1%.

Provenance & Evidence