Methanol → (4-Isopropylthiazol-2-yl)methanol

HRID 443131Notes

Reaction equation

HRID 443131 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([C:9](OC)=[O:10])[S:7][CH:8]=1)([CH3:3])[CH3:2].CO>C(Cl)(Cl)Cl>[OH:10][CH2:9][C:6]1[S:7][CH:8]=[C:4]([CH:1]([CH3:3])[CH3:2])[N:5]=1

Participants

4

Reactant 2

HCID 887MethanolHCID 18759001Methyl 4-propan-2-yl-1,3-thiazole-2-carboxylate

Product 1

HCID 10678505(4-Isopropylthiazol-2-yl)methanolYield 5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using the procedure of Example 5B, but replacing ethyl 2-isopropyl-4-thiazolecarboxylate with methyl 4-isopropylthiazole-2-carboxylate provided, after silica gel chromatography using 2% methanol in chloroform, the desired compound (Rf 0.3, 5% methanol in chloroform) in 96% yield.

Workup

  1. customprovided

Sources & evidence

ORD record
ord-d31887670e8e4192898c4d949a69b2f8
Source dataset
uspto-grants-1999_04
Patent number
US05892052

Reaction notes

Loading…