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HRID443147

反应详情

EQUATION

反应方程式

HRID 443147 的结构方程式

REACTANTS

反应物

2
结构：CC(C)[C@H](NC(=O)N(C)Cc1csc(N2CCCC2)n1)C(=O)O
HCID54281443

未命名化合物

结构：N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccno1
HCID57164722

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@H](NC(=O)N(C)Cc1csc(N2CCCC2)n1)C(=O)N[C@@H](Cc1ccccc1)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccno1
HCID482952

2,4,7,12-Tetraazatridecan-13-oic acid, 10-hydroxy-2-methyl-5-(1-methylethyl)-3,6-dioxo-8,11-bis(phenylmethyl)-1-(2-(1-pyrrolidinyl)-4-thiazolyl)-, 5-isoxazolylmethyl ester, (5S-(5R*,8R*,10R*,11R*))-

C38H49N7O6S

PROCEDURE

实验过程

Using the procedure of Example 1U, but replacing N-((N-methyl-N-((2-isopropyl-4-thiazolyl) methyl)amino)carbonyl)-L-valine with N-((N-methyl-N-((2-(1-pyrrolidinyl)-4-thiazolyl) methyl)amino)carbonyl)-L-valine and replacing (2S,3S,5S)-5-amino-2-(N-((5-thiazolyl)methoxycarbonyl) amino)-1,6-diphenyl-3-hydroxyhexane with (2S,3S,5S)-5-amino-2-(N-((5-isoxazolyl) methoxy-carbonyl)amino)-1,6-diphenyl-3-hydroxyhexane provided, after purification by silica gel chromatography using 2% methanol in chloroform, the desired compound (Rf 0.30, 4% methanol in chloroform).

WORKUP

后处理

  1. customprovided
  2. customafter purification by silica gel chromatography