反应详情

A mixture of styrene (37.0 g, 356 mmol) and the N-methylnitrone solution from Example 5 is heated at 85° C. for 4 hours. After cooling, the phases are separated and the aqueous phase is extracted with chloroform (2×50 g). The combined chloroform extracts are combined with the initial organic phase, and the resultant mixture is washed with water (50 g). The organic phase is dried K2CO3) and stripped of chloroform and excess styrene to give 2-methyl-5-phenylisoxazolidine (16 g).

1. temperatureAfter cooling
2. customthe phases are separated
3. extractionthe aqueous phase is extracted with chloroform (2×50 g)
4. washthe resultant mixture is washed with water (50 g)