Hydrochloric Acid → HCID 15405226, compound

Participants

Reaction Steps

Into a four-mouth flask (volume: 100 ml), in which the inside was substituted by nitrogen, were supplied ether and lithium aluminum hydride (1.9 g; 51 mmol). To this mixture was added dropwise at room temperature an ether solution of 2,2,8-trimethyl-3-oxabicyclo-[4,4,0]- decan-4-one (1 g; 5.1 mmol) which had been separately prepared. The resultant mixture was allowed to react at the same temperature for 1 hour, and the reaction solution was poured into a 10% aqueous solution of hydrochloric acid for separation. The ether layer was separated, washed with brine, dried over anhydrous magnesium sulfate, and concentrated. The resultant crude product was purified by column chromatography on silica gel to give the title compound (3) (0.9 g; 4.5 mmol) (Theoretical yield: 88.2%). Analytical results on the title compound are given below.

Provenance & Evidence