Triethylamine → 4-[(5-Formylimidazol-1-yl)methyl]benzonitrile

Participants

Reaction Steps

To a solution of the alcohol from Step D (21.5 g, 101 mol) in DMSO (500 ml) at room temperature was added triethylamine 56 ml, 402 mmol), then SO3 -pyridine complex (40.5 g, 254 mmol). After 45 min, the reaction was poured into EtOAc, washed with water and brine, dried (Na2SO4), and concentrated in vacuo to provide the aldehyde as a white powder which was sufficiently pure without further purification.

Provenance & Evidence