HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 443220Generated: October 31, 2026
Hydrochloric Acid → HCID 21193404, compound
https://huagongshe.com/reaction/443220
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(1,1-Dimethylethyl) 4-methyl 4-[(2-methylphenyl)methyl]-1,4-piperidinedicarboxylate | HCID 53775443 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21193404 | HCID 21193404 | — |
Reaction Steps
To a solution of N-t-butoxycarbonyl-4-(2-methylbenzyl)-isonipecotic acid methyl ester (7.13 g, 20.5 mmol) in EtOAc (100 ml) at 0° C. was bubbled HCl gas until saturated. The reaction was stirred for 10 min at 0° C. and the solvent evaporated in vacuo to afford the product as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05891889 |
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| Source dataset | uspto-grants-1999_04 |
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| ORD ID | ord-4a1e16fb391b485a8da131711b01c9f0 |
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| Source note | uspto-grants-1999_04 |
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