1-(4-Cyanobenzyl)imidazole-5-carboxylic acid → 4-{5-[4-Hydroxymethyl-4-(2-methylbenzyl)piperidine-1-carbonyl]imidazol-1-ylmethyl}benzonitrile

Participants

Reaction Steps

The title compound was prepared as white solid according to the procedure described in Example 38, Step A-B substituting 1-(4-cyanobenzyl)imidazole-5-acetic acid·lithium chloride with 1-(4-cyanobenzyl)imidazole-5-carboxylic acid and 4-(3-methylbenzyl)-4-hydroxymethylpiperidine hydrochloride salt with 4-(2-methylbenzyl)-4-hydroxymethylpiperidine hydrochloride salt (Example 35) in Step B. The crude product was purified with column chromatography on silica gel eluting with 2-5% methanol in chloroform.

Provenance & Evidence