HRID443269

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID9795357

未命名化合物

HCID21193348

未命名化合物

结构：CCOC(=O)C1(Cc2cccc([N+](=O)[O-])c2)CCN(C(=O)OC(C)(C)C)CC1

HCID53931544

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)C1(Cc2cccc([N+](=O)[O-])c2)CCN(Cc2cnc(C)n2Cc2ccc(C#N)cc2)CC1

HCID21193331

未命名化合物

PROCEDURE

实验过程

The title compound was prepared using the protocol described in Example 61, Step B-C substituting methyl N-tert-butoxycarbonyl-4-(3-methylbenzyl)piperidine-4-carboxylate with ethyl N-tert-butoxycarbonyl-4-(3-nitrobenzyl)piperidine-4-carboxylate in Step B, and 1-(4-cyano-benzyl)-5-chloromethylimidazole hydrochloride salt with 1-(4-cyano-benzyl)-5-chloromethyl-2-methylimidazole hydrochloride salt (Example 53, Step B) in Step C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-99667d348a514220b40532603891398f
来源数据集: uspto-grants-1999_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05891889
来源说明: uspto-grants-1999_04

反应 SMILES

C(O[C:6]([N:8]1[CH2:13][CH2:12][C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-:28])=[O:27])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.C(C1C=CC(CN2C(CCl)=CN=C2)=CC=1)#N.Cl.[C:47]([C:49]1[CH:63]=[CH:62][C:52]([CH2:53][N:54]2[C:58](CCl)=[CH:57][N:56]=[C:55]2[CH3:61])=[CH:51][CH:50]=1)#[N:48]>>[C:47]([C:49]1[CH:50]=[CH:51][C:52]([CH2:53][N:54]2[C:58]([CH2:6][N:8]3[CH2:9][CH2:10][C:11]([CH2:19][C:20]4[CH:25]=[CH:24][CH:23]=[C:22]([N+:26]([O-:28])=[O:27])[CH:21]=4)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13]3)=[CH:57][N:56]=[C:55]2[CH3:61])=[CH:62][CH:63]=1)#[N:48]