HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Cyanobenzyl)imidazole-5-carboxylic acid → methyl 1-[3-(4-cyanobenzyl)-3H-imidazol-4-ylcarbonyl]-4-(3-methylbenzyl)piperidine-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Cyanobenzyl)imidazole-5-carboxylic acid | HCID 15885185 | — |
| Reactant | Methyl 4-(3-methylbenzyl)piperidine-4-carboxylate hydrochloride salt | HCID 21193291 | — |
| Reactant | 1-(4-Cyanobenzyl)imidazole-5-acetic acid.lithium chloride | HCID 23699273 | — |
| Product | methyl 1-[3-(4-cyanobenzyl)-3H-imidazol-4-ylcarbonyl]-4-(3-methylbenzyl)piperidine-4-carboxylate | HCID 15410572 | — |
Reaction Steps
The title compound was prepared according to the procedure described in Example 38, Step B substituting 4-(3-methylbenzyl)-4-hydroxymethylpiperidine hydrochloride salt with methyl 4-(3-methylbenzyl)piperidine-4-carboxylate hydrochloride salt (Example 61, Step B), and 1-(4-cyanobenzyl)imidazole-5-acetic acid·lithium chloride with 1-(4-cyanobenzyl)imidazole-5-carboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05891889 |
| Source dataset | uspto-grants-1999_04 |
| ORD ID | ord-1b0adb41c61740e89785bb3c16e7f28b |
| Source note | uspto-grants-1999_04 |