HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylamine → 2-(2-Hydroxy-2-methylheptyl)-3,5,6-trimethylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylamine | HCID 7912 | — |
| Reactant | 2-Heptanone | HCID 8051 | — |
| Reactant | Tetramethylpyrazine | HCID 14296 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 2-(2-Hydroxy-2-methylheptyl)-3,5,6-trimethylpyrazine | HCID 20444208 | — |
Reaction Steps
The preparation is carried out in the manner described in Example VII using 10.1 grams (0.1 mole) of diisopropylamine in 80 milliliters of ether, 0.95 mole of butyllithium, 13.6 grams (0.1 mole) of tetramethylpyrazine, and 12.8 grams (0.1 mole) of 2-heptanone. The reaction is worked up as before, and the product is isolated by chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04259969 |
| Source dataset | uspto-grants-1981_04 |
| ORD ID | ord-35f5fefee05e43859693bd7783fb1f75 |
| Source note | uspto-grants-1981_04 |