Aniline → HCID 13131705, compound

Participants

Reaction Steps

To 800 ml of methanol 100.0 g. (0.348 mole) of 9-bromo-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid and 100 cm3 of aniline are added. The mixture is heated under stirring until a solution is obtained. The solution is cooled to room temperature and stirred for 2-3 days. The precipitated crystals are filtered and washed with methanol. 64.0 g. (61.4%) of 9-(phenyl-amino)-6-methyl-4-oxo-6,7-dihydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid is obtained which melts at 172°-173° C. after recrystallization from methanol.

Provenance & Evidence