Aniline → 9-(phenyl-amino)-6-methyl-4-oxo-6,7-dihydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester

Participants

Reaction Steps

0.5 g. (2.00 mmoles) of 9-hydroxy-6-methyl-4-oxo-6,7-dihydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester is dissolved in 5 ml. of anhydrous ethanol. To the solution 0.3 g. (3.00 mmoles) of aniline is added and the solution is heated under reflux for 3 hours. The reaction mixture is then cooled and the precipitated crystals are filtered and washed with some ethanol. 0.3 g. (46.1%) of 9-(phenyl-amino)-6-methyl-4-oxo-6,7-dihydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid ethyl ester is obtained, melting point: 119°-120° C.

Provenance & Evidence