4-Bromoaniline → HCID 15584882, compound

Participants

Reaction Steps

2.0 g. (6.97 mmoles) of 9-bromo-6-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid and 1.72 g. of p-bromo-aniline are added to 20 cm3 methanol. The mixture is heated under stirring until a solution is obtained. The solution is cooled to room temperature and stirred for 2-3 days. The precipitated crystals are filtered and washed with methanol. 1.7 g. (64.6%) of 9-[(4-bromo-phenyl)-amino]-6-methyl-4-oxo-6,7-dihydro-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acid is obtained which melts at 202°-204° C. after recrystallization from methanol.

Provenance & Evidence