Hydrochloric Acid → HCID 23467151, compound

Participants

Reaction Steps

To the solution of 0.8 g of 5-hydroxy-2-pyridylacetone in 25 ml of methanol, 0.33 g of cyclopropylamine, 1 ml of 5 N ethereal hydrogen chloride and 1.16 g of sodium cyanoborohydride are added in this order and the mixture is stirred at room temperature for 3 days. The pH thereof is then adjusted to 1 with 5 N ethereal hydrogen chloride, and then to 8 with solid sodium bicarbonate. The mixture is filtered, evaporated and the residue chromatographed on silica gel with ethyl acetate-methanol (4:1) as eluant, to yield 2-(2-cyclopropylaminopropyl)-5-pyridinol. It is converted into its monofumarate as shown in Example 7, melting at 161° with decomposition.

Provenance & Evidence