1-Benzyl-4-piperidone → HCID 23467200, compound

HRID 443425Notes

Reaction equation

HRID 443425 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:8]([CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][NH:11]2)[OH:9])[CH:5]=[CH:6][CH:7]=1.[CH2:16]([N:23]1[CH2:28][CH2:27][C:26](=O)[CH2:25][CH2:24]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH2:16]([N:23]1[CH2:28][CH2:27][C:26]2([N:11]3[CH2:12][CH2:13][CH2:14][CH2:15][CH:10]3[CH:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=3)[O:9]2)[CH2:25][CH2:24]1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 192201-Benzyl-4-piperidoneHCID 23467204HCID 23467204, compound

Product 1

HCID 23467200HCID 23467200, compound

Procedure

Utilizing the procedure described in Example 1 above, 11 g of alpha-(3-fluorophenyl)-2-piperidinemethanol is reacted with 10 g of N-benzyl-4-piperidone to obtain hexahydro-1'-benzyl-1-(3-fluorophenyl)spiro[3H-oxazolo[3,4-a]pyridine-3,4'-piperidine]; mp 113°-115° C. after recrystallizaton from petroleum ether.

Sources & evidence

ORD record
ord-bc0f1ce1e57c4aae97c24deece1a4903
Source dataset
uspto-grants-1981_04
Patent number
US04260623

Reaction notes

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