HCID 23467198, compound → HCID 23467215, compound

Participants

Reaction Steps

Utilizing the procedure described in Example 2 above, 8.9 g of hexahydro-1'-benzyl-1-(2-methoxyphenyl)spiro[3H-oxazolo[3,4-a]pyridine-3,4'-piperidine] is hydrogenated in the presence of a palladium on charcoal catalyst to obtain hexahydro-1-(2-methoxyphenyl)spiro[3H-oxazolo[3,4-a]pyridine-3,4'-piperidine] as an oil after evaporation of the organic layer. The oil, 5.8 g, is dissolved in 30 ml ether and added to a solution of 2.4 g oxalic acid dihydrate in 40 ml of ether. The precipitated solid is collected by filtration and recrystallized from methanol-ethyl acetate to obtain the oxalate salt; mp 185°-186° C.

Provenance & Evidence