Water → HCID 23467211, compound

Participants

Reaction Steps

The hexahydro-1'-(cyclopropylcarbonyl)-1-phenylspiro[3H-oxazolo[3,4-a]pyridine-3,4'-pipridine] used as the starting material in the above procedure can be prepared by the following procedure. Cyclopropanecarboxylic acid chloride, 2 g, is added dropwise to a stirred solution of 4 g of hexahydro-1-phenylspiro[3H-oxazolo[3,4-a]pyridine-3,4'-piperidine] and 2.8 ml of triethylamine in 100 ml of methylene dichloride at 50° C. the reaction mixture is allowed to stand at room temperature overnight and then stirred with 75 ml of water. The organic layer is separated, washed with a saturated aqueous solution of sodium bicarbonate, dried over magnesium sulfate and evaporated to dryness. The residual oil is crystallized from 30 ml of cyclohexane to obtain 4.2 g of hexahydro-1'-(cyclopropylcarbonyl)-1-phenylspiro[3H-oxazolo[3,4-a]pyridine-3,4'-piperidine]; mp 110°-114° C.

Provenance & Evidence