2-Chloropropionyl chloride → HCID 23467277, compound

HRID 443454Notes

Reaction equation

HRID 443454 reaction equation
[Cl:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].Cl.[NH2:8][CH2:9][C:10]#[N:11]>ClC=C(Cl)Cl>[Cl:1][CH:2]([CH3:6])[C:3]([NH:11][CH2:10][C:9]#[N:8])=[O:4]

Participants

4

Reactant 2

HCID 1110192-Chloropropionyl chlorideHCID 11491918Aminoacetonitrile hydrochloride

Product 1

HCID 23467277HCID 23467277, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 6575TrichloroethyleneSolvent

Procedure

In this preparation 42 g of 2-chloropropionyl chloride and 27.8 g aminoacetonitrile hydrochloride were admixed with 100 ml of trichloroethylene and stirred at reflux for 5 hours. The reaction mixture was then filtered and the filtrate was distilled to remove the solvent affording 42.6 g of an oily 2-chloro-N-cyanomethylpropionamide product.

Workup

  1. temperatureat reflux for 5 hours
  2. filtrationThe reaction mixture was then filtered
  3. distillationthe filtrate was distilled
  4. customto remove the solvent

Sources & evidence

ORD record
ord-198dd59a3cb0453ba55e1a02328d8809
Source dataset
uspto-grants-1981_04
Patent number
US04260624

Reaction notes

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